[HTML][HTML] Chromogranin B-induced secretory granule biogenesis: comparison with the similar role of chromogranin A
YH Huh, SH Jeon, SH Yoo - Journal of Biological Chemistry, 2003 - ASBMB
The two major proteins of secretory granules of secretory cells, chromogranins A (CGA) and
B (CGB), have previously been proposed to play key roles in secretory granule biogenesis.
Recently, CGA was reported to play an on/off switch role for secretory granule biogenesis. In
the present study we found CGB being more effective than CGA in inducing secretory
granule formation in non-neuroendocrine NIH3T3 and COS-7 cells. The mean number of
dense core granules formed/cell of CGA-transfected NIH3T3 cells was 2.51, whereas that of …
B (CGB), have previously been proposed to play key roles in secretory granule biogenesis.
Recently, CGA was reported to play an on/off switch role for secretory granule biogenesis. In
the present study we found CGB being more effective than CGA in inducing secretory
granule formation in non-neuroendocrine NIH3T3 and COS-7 cells. The mean number of
dense core granules formed/cell of CGA-transfected NIH3T3 cells was 2.51, whereas that of …