An early postnatal oxytocin treatment prevents social and learning deficits in adult mice deficient for Magel2, a gene involved in Prader-Willi syndrome and autism
H Meziane, F Schaller, S Bauer, C Villard… - Biological …, 2015 - Elsevier
Background Mutations of MAGEL2 have been reported in patients presenting with autism,
and loss of MAGEL2 is also associated with Prader-Willi syndrome, a neurodevelopmental
genetic disorder. This study aimed to determine the behavioral phenotype of Magel2-
deficient adult mice, to characterize the central oxytocin (OT) system of these mutant mice,
and to test the curative effect of a peripheral OT treatment just after birth. Methods We
assessed the social and cognitive behavior of Magel2-deficient mice, analyzed the OT …
and loss of MAGEL2 is also associated with Prader-Willi syndrome, a neurodevelopmental
genetic disorder. This study aimed to determine the behavioral phenotype of Magel2-
deficient adult mice, to characterize the central oxytocin (OT) system of these mutant mice,
and to test the curative effect of a peripheral OT treatment just after birth. Methods We
assessed the social and cognitive behavior of Magel2-deficient mice, analyzed the OT …