Endocrine and metabolic aspects of adult Prader–Willi syndrome with special emphasis on the effect of growth hormone treatment
C Höybye - Growth hormone & IGF research, 2004 - Elsevier
Prader-Willi syndrome (PWS) is a genetic disorder characterized by mild mental retardation,
short stature, abnormal body composition, muscular hypotonia and distinctive behavioural
features. Excessive eating causes progressive obesity with increased cardiovascular
morbidity and mortality. In the PWS genotype loss of one or more normally active paternal
genes in region q11-13 on chromosome 15 is seen. It is supposed that the genetic alteration
leads to dysfunction of several hypothalamic centres and growth hormone (GH) deficiency …
short stature, abnormal body composition, muscular hypotonia and distinctive behavioural
features. Excessive eating causes progressive obesity with increased cardiovascular
morbidity and mortality. In the PWS genotype loss of one or more normally active paternal
genes in region q11-13 on chromosome 15 is seen. It is supposed that the genetic alteration
leads to dysfunction of several hypothalamic centres and growth hormone (GH) deficiency …