Duchenne muscular dystrophy is a life-limiting muscle disease that has no current effective
therapy. Despite mounting evidence that dysregulation of mechanosensitive ion channels is
a significant contributor to dystrophy pathogenesis, effective pharmacologic strategies
targeting these channels are lacking. GsMTx4, and its enantiomer GsMTx4-D, are peptide
inhibitors of mechanosensitive channels with identical activity. In previous studies, acute in
vitro application of GsMTx4 to dystrophic murine muscle effectively reduced the excess MSC …