Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: results from the Cardiovascular Health Study

J Walston, MA McBurnie, A Newman… - Archives of internal …, 2002 - jamanetwork.com
Background The biological basis of frailty has been difficult to establish owing to the lack of a
standard definition, its complexity, and its frequent coexistence with illness. Objective To
establish the biological correlates of frailty in the presence and absence of concurrent
cardiovascular disease and diabetes mellitus. Methods Participants were 4735 community-
dwelling adults 65 years and older. Frail, intermediate, and nonfrail subjects were identified
by a validated screening tool and exclusion criteria. Bivariate relationships between frailty …