[HTML][HTML] The prodomain-bound form of bone morphogenetic protein 10 is biologically active on endothelial cells
H Jiang, RM Salmon, PD Upton, Z Wei… - Journal of Biological …, 2016 - ASBMB
BMP10 is highly expressed in the developing heart and plays essential roles in
cardiogenesis. BMP10 deletion in mice results in embryonic lethality because of impaired
cardiac development. In adults, BMP10 expression is restricted to the right atrium, though
ventricular hypertrophy is accompanied by increased BMP10 expression in a rat
hypertension model. However, reports of BMP10 activity in the circulation are inconclusive.
In particular, it is not known whether in vivo secreted BMP10 is active or whether additional …
cardiogenesis. BMP10 deletion in mice results in embryonic lethality because of impaired
cardiac development. In adults, BMP10 expression is restricted to the right atrium, though
ventricular hypertrophy is accompanied by increased BMP10 expression in a rat
hypertension model. However, reports of BMP10 activity in the circulation are inconclusive.
In particular, it is not known whether in vivo secreted BMP10 is active or whether additional …