Potential role of UGT1A4 promoter SNPs in anastrozole pharmacogenomics
VK Edavana, IB Dhakal, S Williams, R Penney… - Drug Metabolism and …, 2013 - Elsevier
Anastrozole belongs to the nonsteroidal triazole-derivative group of aromatase inhibitors.
Recently, clinical trials demonstrated improved antitumoral efficacy and a favorable toxicity
with third-generation aromatase inhibitors, compared with tamoxifen. Anastrozole is
predominantly metabolized by phase I oxidation with the potential for further phase II
glucuronidation. It also, however, is subject to direct N-glucuronidation by UDP-
glucuronosyltransferase 1A4 (UGT1A4). Anastrozole pharmacokinetics vary widely among …
Recently, clinical trials demonstrated improved antitumoral efficacy and a favorable toxicity
with third-generation aromatase inhibitors, compared with tamoxifen. Anastrozole is
predominantly metabolized by phase I oxidation with the potential for further phase II
glucuronidation. It also, however, is subject to direct N-glucuronidation by UDP-
glucuronosyltransferase 1A4 (UGT1A4). Anastrozole pharmacokinetics vary widely among …
