Purpose We determined hormone concentrations (estradiol [E2], estrone [E1], estrone
conjugates [E1-C], androstenedione [A], testosterone [T]) before and on anastrozole therapy
where we also determined plasma concentrations of anastrozole and its metabolites.
Experimental Postmenopausal women who were to receive adjuvant anastrozole for
resected early breast cancer were studied. Pretreatment, blood samples were obtained for
the acquisition of DNA and for plasma hormone measurements (E2, E1, E1-C, A, and T). A …