[HTML][HTML] Yap1 protein regulates vascular smooth muscle cell phenotypic switch by interaction with myocardin

C Xie, Y Guo, T Zhu, J Zhang, PX Ma… - Journal of Biological …, 2012 - ASBMB
The Hippo-Yap (Yes-associated protein) signaling pathway has emerged as one of the
critical pathways regulating cell proliferation, differentiation, and apoptosis in response to
environmental and developmental cues. However, Yap1 roles in vascular smooth muscle
cell (VSMC) biology have not been investigated. VSMCs undergo phenotypic switch, a
process characterized by decreased gene expression of VSMC contractile markers and
increased proliferation, migration, and matrix synthesis. The goals of the present studies …