Expansion of human tumor infiltrating lymphocytes for use in immunotherapy trials
SL Topalian, LM Muul, D Solomon… - Journal of immunological …, 1987 - Elsevier
The potential utility of tumor-infiltrating lymphocytes (TIL) in the adoptive immunotherapy of
human tumors has been suggested by murine experiments showing these cells to be 50–
100 times more powerful than LAK cells in treating advanced metastatic disease. A method
for the large-scale expansion of human TIL for the use of these cells in clinical trials is
described in this report. TIL were successfully expanded on an experimental scale from 24
of 25 consecutive human tumors, including six melanomas, ten sarcomas, and eight …
human tumors has been suggested by murine experiments showing these cells to be 50–
100 times more powerful than LAK cells in treating advanced metastatic disease. A method
for the large-scale expansion of human TIL for the use of these cells in clinical trials is
described in this report. TIL were successfully expanded on an experimental scale from 24
of 25 consecutive human tumors, including six melanomas, ten sarcomas, and eight …