[HTML][HTML] Prognostic significance of FOXL2 mutation and mRNA expression in adult and juvenile granulosa cell tumors of the ovary
E D'angelo, A Mozos, D Nakayama, I Espinosa… - Modern Pathology, 2011 - Elsevier
Recently, mutation of the FOXL2 gene has been consistently identified in adult granulosa
cell tumors of the ovary. The purpose of this study is to investigate whether the FOXL2
mutation and mRNA expression have a role in the pathogenesis of juvenile and adult
granulosa cell tumors and influence tumor progression. Thirty-four adult granulosa cell
tumors and 20 juvenile granulosa cell tumors were examined for the presence of the FOXL2
(C402G) mutation. Expression levels were studied by quantitative PCR and …
cell tumors of the ovary. The purpose of this study is to investigate whether the FOXL2
mutation and mRNA expression have a role in the pathogenesis of juvenile and adult
granulosa cell tumors and influence tumor progression. Thirty-four adult granulosa cell
tumors and 20 juvenile granulosa cell tumors were examined for the presence of the FOXL2
(C402G) mutation. Expression levels were studied by quantitative PCR and …