Insulin-like growth factor I gene transfer to cirrhotic liver induces fibrolysis and reduces fibrogenesis leading to cirrhosis reversion in rats
L Sobrevals, C Rodriguez, JL Romero-Trevejo… - Hepatology, 2010 - journals.lww.com
We investigated whether gene transfer of insulin-like growth factor I (IGF-I) to the hepatic
tissue was able to improve liver histology and function in established liver cirrhosis. Rats
with liver cirrhosis induced by carbon tetrachloride (CCl 4) given orally for 8 weeks were
injected through the hepatic artery with saline or with Simian virus 40 vectors encoding IGF-I
(SVIGF-I), or luciferase (SVLuc). Animals were sacrificed 8 weeks after vector injection. In
cirrhotic rats we observed that, whereas IGF-I was synthesized by hepatocytes, IGF-I …
tissue was able to improve liver histology and function in established liver cirrhosis. Rats
with liver cirrhosis induced by carbon tetrachloride (CCl 4) given orally for 8 weeks were
injected through the hepatic artery with saline or with Simian virus 40 vectors encoding IGF-I
(SVIGF-I), or luciferase (SVLuc). Animals were sacrificed 8 weeks after vector injection. In
cirrhotic rats we observed that, whereas IGF-I was synthesized by hepatocytes, IGF-I …