[HTML][HTML] A randomized, placebo‐controlled trial of cenicriviroc for treatment of nonalcoholic steatohepatitis with fibrosis
SL Friedman, V Ratziu, SA Harrison, MF Abdelmalek… - Hepatology, 2018 - journals.lww.com
Emerging studies have suggested that the Hippo pathway is involved in the tumorigenesis of
hepatocellular carcinoma (HCC). However, the key regulator of the Hippo pathway in liver
tumor metabolic reprogramming remains elusive. Here, we provide evidence that high
mobility group box 1 (HMGB1), a chromosomal protein, plays a role in the regulation of the
Hippo pathway during liver tumorigenesis. Cre/loxP recombination‐mediated HMGB1
depletion in hepatocytes blocks diethylnitrosamine‐induced liver cancer initiation in mice …
hepatocellular carcinoma (HCC). However, the key regulator of the Hippo pathway in liver
tumor metabolic reprogramming remains elusive. Here, we provide evidence that high
mobility group box 1 (HMGB1), a chromosomal protein, plays a role in the regulation of the
Hippo pathway during liver tumorigenesis. Cre/loxP recombination‐mediated HMGB1
depletion in hepatocytes blocks diethylnitrosamine‐induced liver cancer initiation in mice …