The influence of growth hormone replacement on peripheral inflammatory and cardiovascular risk markers in adults with severe growth hormone deficiency

D Deepak, C Daousi, M Javadpour, D Clark… - Growth Hormone & IGF …, 2010 - Elsevier
BACKGROUND: Adult GHD syndrome is associated with clustering of adverse
cardiovascular (CV) risk factors such as abnormal body composition, dyslipidemia, insulin
resistance and abnormal haemostatic factors. There is a wealth of evidence linking CV
events with elevated levels of inflammatory markers (hs-CRP and IL-6) in the general
population; however data on their abnormalities in GHD and specially the effects of GH
replacement (GHR) on these inflammatory markers are limited. OBJECTIVE: To study the …