Increased hepatic and circulating interleukin-6 levels in human nonalcoholic steatohepatitis
A Wieckowska, BG Papouchado, ZZ Li… - Official journal of the …, 2008 - journals.lww.com
A Wieckowska, BG Papouchado, ZZ Li, R Lopez, NN Zein, AE Feldstein
Official journal of the American College of Gastroenterology| ACG, 2008•journals.lww.comBACKGROUND Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D) are
growing public health problems, and are strongly associated. The link between the two
conditions remains poorly understood. Hepatic interleukin-6 (IL-6), a major proinflammatory
cytokine, expression is increased in animal models of NAFLD, while in mice, selective
sustained upregulation of IL-6 in the liver results in systemic insulin resistance. The extent
and clinical significance of hepatic IL-6 expression in human NAFLD, as well as potential …
growing public health problems, and are strongly associated. The link between the two
conditions remains poorly understood. Hepatic interleukin-6 (IL-6), a major proinflammatory
cytokine, expression is increased in animal models of NAFLD, while in mice, selective
sustained upregulation of IL-6 in the liver results in systemic insulin resistance. The extent
and clinical significance of hepatic IL-6 expression in human NAFLD, as well as potential …
Abstract
BACKGROUND
Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D) are growing public health problems, and are strongly associated. The link between the two conditions remains poorly understood. Hepatic interleukin-6 (IL-6), a major proinflammatory cytokine, expression is increased in animal models of NAFLD, while in mice, selective sustained upregulation of IL-6 in the liver results in systemic insulin resistance. The extent and clinical significance of hepatic IL-6 expression in human NAFLD, as well as potential mechanisms by which steatosis may increase IL-6 production in the liver, have not been examined.
AIMS
To ascertain the occurrence and significance of IL-6 expression in the liver in human NAFLD.
Lippincott Williams & Wilkins