Gene expression of tumor necrosis factor [alpha] and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients
J Crespo, P Fern, M Hern, M Mayorga, F Pons-Romero - Hepatology, 2001 - Elsevier
The main objective of this study was to analyze the pathogenic role of the tumor necrosis
factor [alpha](TNF-[alpha]) system in the development of nonalcoholic steatohepatitis
(NASH). Fifty-two obese patients were studied. We investigated:(1) the expression of mRNA
of TNF-[alpha] and their p55 and p75-receptors by quantitative reverse-transcriptase
polymerase chain reaction (RT-PCR) in hepatic and adipose tissues; and (2) the
relationship between TNF-[alpha], p55, and p75 and the severity of NASH. Obese patients …
factor [alpha](TNF-[alpha]) system in the development of nonalcoholic steatohepatitis
(NASH). Fifty-two obese patients were studied. We investigated:(1) the expression of mRNA
of TNF-[alpha] and their p55 and p75-receptors by quantitative reverse-transcriptase
polymerase chain reaction (RT-PCR) in hepatic and adipose tissues; and (2) the
relationship between TNF-[alpha], p55, and p75 and the severity of NASH. Obese patients …