A systematic review of studies examining the rate of lung function decline in patients with cystic fibrosis

SN Harun, C Wainwright, K Klein, S Hennig - Paediatric respiratory reviews, 2016 - Elsevier
A systematic review was performed (i) to describe the reported overall rate of progression of
CF lung disease quantified as FEV 1% predicted decline with age,(ii) to summarise
identified influencing risk factors and (iii) to review methods used to analyse CF lung
disease progression data. A search of publications providing FEV 1% predicted values over
age was conducted in PUBMED and EMBASE. Baseline and rate of FEV 1% predicted
decline were summarised overall and by identified risk factors. Thirty-nine studies were …