Airway diseases, including cigarette smoke-induced chronic bronchitis, cystic fibrosis, and
primary ciliary dyskinesia are associated with decreased mucociliary clearance (MCC).
However, it is not known whether a simple reduction in MCC or concentration-dependent
mucus adhesion to airway surfaces dominates disease pathogenesis or whether decreasing
the concentration of secreted mucins may be therapeutic. To address these questions,
Scnn1b-Tg mice, which exhibit airway mucus dehydration/adhesion, were compared and …