[HTML][HTML] Disruption of the K+ channel β-subunit KCNE3 reveals an important role in intestinal and tracheal Cl− transport
P Preston, L Wartosch, D Günzel, M Fromm… - Journal of Biological …, 2010 - ASBMB
The KCNE3 β-subunit constitutively opens outwardly rectifying KCNQ1 (Kv7. 1) K+ channels
by abolishing their voltage-dependent gating. The resulting KCNQ1/KCNE3 heteromers
display enhanced sensitivity to K+ channel inhibitors like chromanol 293B. KCNE3 was also
suggested to modify biophysical properties of several other K+ channels, and a mutation in
KCNE3 was proposed to underlie forms of human periodic paralysis. To investigate
physiological roles of KCNE3, we now disrupted its gene in mice. kcne3−/− mice were viable …
by abolishing their voltage-dependent gating. The resulting KCNQ1/KCNE3 heteromers
display enhanced sensitivity to K+ channel inhibitors like chromanol 293B. KCNE3 was also
suggested to modify biophysical properties of several other K+ channels, and a mutation in
KCNE3 was proposed to underlie forms of human periodic paralysis. To investigate
physiological roles of KCNE3, we now disrupted its gene in mice. kcne3−/− mice were viable …