[HTML][HTML] RelB forms transcriptionally inactive complexes with RelA/p65
R Marienfeld, MJ May, I Berberich, E Serfling… - Journal of Biological …, 2003 - ASBMB
RelB is an unusual member of the NF-κB transcription factor family that acts as both a
transcriptional activator as well as a repressor of NF-κB-dependent gene expression.
Although RelB promotes gene expression when it associates with p50/NF-κB1 or p52/NF-
κB2, the precise molecular mechanisms through which it represses NF-κB remain unclear.
To examine this inhibitory function in more detail, we employed reporter gene assays and
found that RelB represses at the level of RelA. Furthermore, electrophoretic mobility shift …
transcriptional activator as well as a repressor of NF-κB-dependent gene expression.
Although RelB promotes gene expression when it associates with p50/NF-κB1 or p52/NF-
κB2, the precise molecular mechanisms through which it represses NF-κB remain unclear.
To examine this inhibitory function in more detail, we employed reporter gene assays and
found that RelB represses at the level of RelA. Furthermore, electrophoretic mobility shift …