Dysfunctional T cell metabolism in the tumor microenvironment

KE Beckermann, SO Dudzinski, JC Rathmell - Cytokine & growth factor …, 2017 - Elsevier
Metabolic and signaling pathways are integrated to determine T cell fate and function. As
stimulated T cells gain distinct effector functions, specific metabolic programs and demands
are also adopted. These changes are essential for T cell effector function, and alterations or
dysregulation of metabolic pathways can modulate T cell function. One physiological setting
that impacts T cell metabolism is the tumor microenvironment. The metabolism of cancer
cells themselves can limit nutrients and accumulate waste products. In addition to the …