[HTML][HTML] EGF signaling activates proliferation and blocks apoptosis of mouse and human intestinal stem/progenitor cells in long-term monolayer cell culture
A Suzuki, S Sekiya, E Gunshima, S Fujii… - Laboratory …, 2010 - Elsevier
The homeostatic renewal of the intestinal epithelium depends on regulation of proliferation
and differentiation of stem/progenitor cells residing in a specific site, called the 'stem cell
niche.'Thus, the reconstitution of the microenvironment of the stem cell niche may allow us to
maintain intestinal stem/progenitor cells in culture for a longer period. Although epidermal
growth factor (EGF) is conventionally used as a supplement of intestinal epithelial cell
culture, little has been known regarding a role of EGF signaling in a stem/progenitor cell …
and differentiation of stem/progenitor cells residing in a specific site, called the 'stem cell
niche.'Thus, the reconstitution of the microenvironment of the stem cell niche may allow us to
maintain intestinal stem/progenitor cells in culture for a longer period. Although epidermal
growth factor (EGF) is conventionally used as a supplement of intestinal epithelial cell
culture, little has been known regarding a role of EGF signaling in a stem/progenitor cell …