[HTML][HTML] Angiotensin II and epidermal growth factor induce cyclooxygenase-2 expression in intestinal epithelial cells through small GTPases using distinct signaling …
LW Slice, T Chiu, E Rozengurt - Journal of Biological Chemistry, 2005 - ASBMB
Colorectal carcinogenesis is a multistep process involving genetic mutations and alterations
in rigorously controlled signaling pathways and gene expression that control intestinal
epithelial cell proliferation, differentiation, and apoptosis. Cyclooxygenase-2 (COX-2) is
aberrantly expressed in premalignant adenomatous polyps and colorectal carcinomas and
is associated with increased epithelial cell proliferation, decreased apoptosis, and increased
cell invasiveness. Currently, knowledge of the regulation of expression of COX-2 by …
in rigorously controlled signaling pathways and gene expression that control intestinal
epithelial cell proliferation, differentiation, and apoptosis. Cyclooxygenase-2 (COX-2) is
aberrantly expressed in premalignant adenomatous polyps and colorectal carcinomas and
is associated with increased epithelial cell proliferation, decreased apoptosis, and increased
cell invasiveness. Currently, knowledge of the regulation of expression of COX-2 by …