C-terminal di-arginine motif of Cdc42 protein is essential for binding to phosphatidylinositol 4, 5-bisphosphate-containing membranes and inducing cellular …
JL Johnson, JW Erickson, RA Cerione - Journal of Biological Chemistry, 2012 - jbc.org
Rho GTPases regulate a diverse range of processes that are dependent on their proper
cellular localization. The membrane localization of these GTPases is due in large part to
their carboxyl-terminal geranylgeranyl moiety. In addition, most of the Rho family members
contain a cluster of positively charged residues (ie a" polybasic domain"), directly preceding
their geranylgeranyl moiety, and it has been suggested that this domain serves to fine-tune
their localization among different cellular membrane sites. Here, we have taken a closer look …
cellular localization. The membrane localization of these GTPases is due in large part to
their carboxyl-terminal geranylgeranyl moiety. In addition, most of the Rho family members
contain a cluster of positively charged residues (ie a" polybasic domain"), directly preceding
their geranylgeranyl moiety, and it has been suggested that this domain serves to fine-tune
their localization among different cellular membrane sites. Here, we have taken a closer look …
