Histone deacetylases (HDACs) are part of the epigenetic machinery that regulates
transcriptional processes. The current paradigm is that HDACs silence gene expression via
regulation of histone protein lysine deacetylation, or by forming corepressor complexes with
transcription factors. However, HDACs are more than just nuclear proteins, and they can
interact and deacetylate a growing number of nonhistone proteins to regulate cellular
function. Cancer-field studies have shown that deranged HDAC activity results in …