Inflammatory responses in the peripheral (PNS) and central nervous systems (CNS) play
key roles in the development and persistence of many pathologic pain states. 1 Certain
inflammatory cytokines in spinal cord, dorsal root ganglion (DRG), injured nerve or skin are
known to be associated with pain behaviors and with the generation of abnormal
spontaneous activity from injured nerve fibers or compressed/inflamed DRG neurons.
Cytokines are small secreted proteins released by cells have a specific effect on the …