[HTML][HTML] Spontaneous development of endoplasmic reticulum stress that can lead to diabetes mellitus is associated with higher calcium-independent phospholipase …
X Lei, S Zhang, SE Barbour, A Bohrer, EL Ford… - Journal of Biological …, 2010 - ASBMB
Our recent studies indicate that endoplasmic reticulum (ER) stress causes INS-1 cell
apoptosis by a Ca 2+-independent phospholipase A 2 (iPLA 2 β)-mediated mechanism that
promotes ceramide generation via sphingomyelin hydrolysis and subsequent activation of
the intrinsic pathway. To elucidate the association between iPLA 2 β and ER stress, we
compared β-cell lines generated from wild type (WT) and Akita mice. The Akita mouse is a
spontaneous model of ER stress that develops hyperglycemia/diabetes due to ER stress …
apoptosis by a Ca 2+-independent phospholipase A 2 (iPLA 2 β)-mediated mechanism that
promotes ceramide generation via sphingomyelin hydrolysis and subsequent activation of
the intrinsic pathway. To elucidate the association between iPLA 2 β and ER stress, we
compared β-cell lines generated from wild type (WT) and Akita mice. The Akita mouse is a
spontaneous model of ER stress that develops hyperglycemia/diabetes due to ER stress …