[HTML][HTML] Macrophage polarization is linked to Ca2+-independent phospholipase A2β-derived lipids and cross-cell signaling in mice [S]
AJ Nelson, DJ Stephenson, CL Cardona, X Lei… - Journal of Lipid …, 2020 - ASBMB
Phospholipases A 2 (PLA 2 s) catalyze hydrolysis of the sn-2 substituent from
glycerophospholipids to yield a free fatty acid (ie, arachidonic acid), which can be
metabolized to pro-or anti-inflammatory eicosanoids. Macrophages modulate inflammatory
responses and are affected by Ca 2+-independent phospholipase A 2 (PLA 2) β (iPLA 2 β).
Here, we assessed the link between iPLA 2 β-derived lipids (iDLs) and macrophage
polarization. Macrophages from WT and KO (iPLA 2 β−/−) mice were classically M1 pro …
glycerophospholipids to yield a free fatty acid (ie, arachidonic acid), which can be
metabolized to pro-or anti-inflammatory eicosanoids. Macrophages modulate inflammatory
responses and are affected by Ca 2+-independent phospholipase A 2 (PLA 2) β (iPLA 2 β).
Here, we assessed the link between iPLA 2 β-derived lipids (iDLs) and macrophage
polarization. Macrophages from WT and KO (iPLA 2 β−/−) mice were classically M1 pro …