[HTML][HTML] Polarization of macrophages toward M2 phenotype is favored by reduction in iPLA2β (group VIA phospholipase A2)
JW Ashley, WD Hancock, AJ Nelson, RN Bone… - Journal of Biological …, 2016 - ASBMB
Macrophages are important in innate and adaptive immunity. Macrophage participation in
inflammation or tissue repair is directed by various extracellular signals and mediated by
multiple intracellular pathways. Activation of group VIA phospholipase A 2 (iPLA 2 β) causes
accumulation of arachidonic acid, lysophospholipids, and eicosanoids that can promote
inflammation and pathologic states. We examined the role of iPLA 2 β in peritoneal
macrophage immune function by comparing wild type (WT) and iPLA 2 β−/− mouse …
inflammation or tissue repair is directed by various extracellular signals and mediated by
multiple intracellular pathways. Activation of group VIA phospholipase A 2 (iPLA 2 β) causes
accumulation of arachidonic acid, lysophospholipids, and eicosanoids that can promote
inflammation and pathologic states. We examined the role of iPLA 2 β in peritoneal
macrophage immune function by comparing wild type (WT) and iPLA 2 β−/− mouse …