[HTML][HTML] Defining natural antibodies

NE Holodick, N Rodríguez-Zhurbenko… - Frontiers in …, 2017 - frontiersin.org
NE Holodick, N Rodríguez-Zhurbenko, AM Hernández
Frontiers in immunology, 2017frontiersin.org
The traditional definition of natural antibodies (NAbs) states that these antibodies are
present prior to the body encountering cognate antigen, providing a first line of defense
against infection thereby, allowing time for a specific antibody response to be mounted. The
literature has a seemingly common definition of NAbs; however, as our knowledge of
antibodies and B cells is refined, re-evaluation of the common definition of Nabs may be
required. Defining Nabs becomes important as the function of NAb production is used to …
The traditional definition of natural antibodies (NAbs) states that these antibodies are present prior to the body encountering cognate antigen, providing a first line of defense against infection thereby, allowing time for a specific antibody response to be mounted. The literature has a seemingly common definition of NAbs; however, as our knowledge of antibodies and B cells is refined, re-evaluation of the common definition of Nabs may be required. Defining Nabs becomes important as the function of NAb production is used to define B cell subsets and as these important molecules are shown to play numerous roles in the immune system (Figure ). Herein, we aim to briefly summarize our current knowledge of NAbs in the context of initiating a discussion within the field of how such an important and multifaceted group of molecules should be defined.
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