Intramyocardial injection of mesenchymal precursor cells and successful temporary weaning from left ventricular assist device support in patients with advanced heart …

TM Yau, FD Pagani, DM Mancini, HL Chang, A Lala… - Jama, 2019 - jamanetwork.com
Importance Left ventricular assist device (LVAD) therapy improves myocardial function, but
few patients recover sufficiently for explant, which has focused attention on stem cells to
augment cardiac recovery. Objective To assess efficacy and adverse effects of
intramyocardial injections of mesenchymal precursor cells (MPCs) during LVAD implant.
Design, Setting, and Participants A randomized phase 2 clinical trial involving patients with
advanced heart failure, undergoing LVAD implant, at 19 North American centers (July 2015 …