[HTML][HTML] Anthracycline inhibits recruitment of hypoxia-inducible transcription factors and suppresses tumor cell migration and cardiac angiogenic response in the host
T Tanaka, J Yamaguchi, K Shoji, M Nangaku - Journal of Biological …, 2012 - ASBMB
Anthracycline chemotherapeutic agents of the topoisomerase inhibitor family are widely
used for the treatment of various tumors. Although targeted tumor tissues are generally
situated in a hypoxic environment, the connection between efficacy of anthracycline agents
and cellular hypoxia response has not been investigated in depth. Here, we report that
doxorubicin (DXR) impairs the transcriptional response of the hypoxia-inducible factor (HIF)
by inhibiting the binding of the HIF heterodimer to the consensus-RCGTG-enhancer …
used for the treatment of various tumors. Although targeted tumor tissues are generally
situated in a hypoxic environment, the connection between efficacy of anthracycline agents
and cellular hypoxia response has not been investigated in depth. Here, we report that
doxorubicin (DXR) impairs the transcriptional response of the hypoxia-inducible factor (HIF)
by inhibiting the binding of the HIF heterodimer to the consensus-RCGTG-enhancer …