[HTML][HTML] Angiopoietin-2, an angiogenic regulator, promotes initial growth and survival of breast cancer metastases to the lung through the integrin-linked kinase (ILK) …
Y Imanishi, B Hu, G Xiao, X Yao, SY Cheng - Journal of Biological …, 2011 - ASBMB
The early onsets of breast cancer metastasis involve cell retention, survival, and resistant to
apoptosis and subsequent growth at target vascular beds and tissues in distant organs. We
previously reported that angiopoietin-2 (Ang2), an angiogenic regulator stimulates MCF-7
breast tumor metastasis from their orthotopic sites to distant organs through the α 5 β 1
integrin/integrin-linked kinase (ILK)/Akt pathway. Here, by using an experimental tumor
metastasis model and in vitro studies, we further dissect the underlying mechanism by which …
apoptosis and subsequent growth at target vascular beds and tissues in distant organs. We
previously reported that angiopoietin-2 (Ang2), an angiogenic regulator stimulates MCF-7
breast tumor metastasis from their orthotopic sites to distant organs through the α 5 β 1
integrin/integrin-linked kinase (ILK)/Akt pathway. Here, by using an experimental tumor
metastasis model and in vitro studies, we further dissect the underlying mechanism by which …