TLR2 enhances NADPH oxidase activity and killing of Staphylococcus aureus by PMN
NJ Jann, M Schmaler, F Ferracin, R Landmann - Immunology letters, 2011 - Elsevier
Toll-like receptors play an essential role in the detection of invading pathogens. TLR2 is
expressed in high concentrations on neutrophils and has been implicated as a critical
mediator inducing host antimicrobial defenses against Gram-positive bacteria. Neutrophil
responses induced via TLR2 are likely to have important clinical consequences, since Gram-
positive organisms, such as Staphylococcus aureus, are an increasingly important source of
severe infections. In the present study, we report that TLR2 has a central role in killing of S …
expressed in high concentrations on neutrophils and has been implicated as a critical
mediator inducing host antimicrobial defenses against Gram-positive bacteria. Neutrophil
responses induced via TLR2 are likely to have important clinical consequences, since Gram-
positive organisms, such as Staphylococcus aureus, are an increasingly important source of
severe infections. In the present study, we report that TLR2 has a central role in killing of S …