[HTML][HTML] A genomic and proteomic analysis of activation of the human neutrophil by lipopolysaccharide and its mediation by p38 mitogen-activated protein kinase
MB Fessler, KC Malcolm, MW Duncan… - Journal of Biological …, 2002 - ASBMB
Bacterial lipopolysaccharide (LPS) evokes several functional responses in the neutrophil
that contribute to innate immunity. Although certain responses, such as adhesion and
synthesis of tumor necrosis factor-α, are inhibited by pretreatment with an inhibitor of p38
mitogen-activated protein kinase, others, such as actin assembly, are unaffected. The aim of
the present study was to investigate the changes in neutrophil gene transcription and protein
expression following lipopolysaccharide exposure and to establish their dependence on …
that contribute to innate immunity. Although certain responses, such as adhesion and
synthesis of tumor necrosis factor-α, are inhibited by pretreatment with an inhibitor of p38
mitogen-activated protein kinase, others, such as actin assembly, are unaffected. The aim of
the present study was to investigate the changes in neutrophil gene transcription and protein
expression following lipopolysaccharide exposure and to establish their dependence on …