proteomic approaches to fundamental questions about neutrophil biology

KR McLeish, ML Merchant, JB Klein… - Journal of leukocyte …, 2013 - academic.oup.com
Journal of leukocyte biology, 2013academic.oup.com
Proteomics is one of a group of technologies that generates high-throughput, large-scale
datasets that can be used to understand cell or organ functions at a systems level. This
review will focus on the application of proteomics to the understanding of neutrophil biology.
The strengths and weaknesses of common proteomic methods and their application to
neutrophils are reviewed, with the goal of evaluating whether the technology is ready to
advance our understanding of neutrophil biology.
Abstract
Proteomics is one of a group of technologies that generates high-throughput, large-scale datasets that can be used to understand cell or organ functions at a systems level. This review will focus on the application of proteomics to the understanding of neutrophil biology. The strengths and weaknesses of common proteomic methods and their application to neutrophils are reviewed, with the goal of evaluating whether the technology is ready to advance our understanding of neutrophil biology.
Oxford University Press