[HTML][HTML] Bromodomain and extraterminal (BET) protein inhibition suppresses human T cell leukemia virus 1 (HTLV-1) Tax protein-mediated tumorigenesis by inhibiting …

X Wu, J Qi, JE Bradner, G Xiao, LF Chen - Journal of Biological Chemistry, 2013 - ASBMB
The etiology of human T cell leukemia virus 1 (HTLV-1)-mediated adult T cell leukemia is
associated with the ability of viral oncoprotein Tax to induce sustained NF-κB activation and
the expression of many NF-κB target genes. Acetylation of the RelA subunit of NF-κB and the
subsequent recruitment of bromodomain-containing factor Brd4 are important for the
expression of NF-κB target genes in response to various stimuli. However, their contributions
to Tax-mediated NF-κB target gene expression and tumorigenesis remain unclear. Here we …