Management of COVID-19 respiratory distress

JJ Marini, L Gattinoni - Jama, 2020 - jamanetwork.com
Acute respiratory distress syndrome (ARDS) can originate from either the gas or vascular
side of the alveolus. Although the portal for coronavirus disease 2019 (COVID-19) is
inhalational, and alveolar infiltrates are commonly found on chest x-ray or computed
tomography (CT) scan, the respiratory distress appears to include an important vascular
insult that potentially mandates a different treatment approach than customarily applied for
ARDS. Indeed, the wide variation in mortality rates across different intensive care units …