C5b9 formation on endothelial cells reflects complement defects among patients with renal thrombotic microangiopathy and severe hypertension
SA Timmermans, MA Abdul-Hamid… - Journal of the …, 2018 - journals.lww.com
Background Severe hypertension can induce thrombotic microangiopathy (TMA) in the renal
vasculature, the occurrence of which has been linked to mechanical stress to the
endothelium. Complement defects may be the culprit of disease in patients who present with
severe renal disease and often progress to ESRD, despite BP control. Methods We studied
a well defined cohort of 17 patients with hypertension-associated TMA to define the
prevalence of complement defects by a specific ex vivo serum-based microvascular …
vasculature, the occurrence of which has been linked to mechanical stress to the
endothelium. Complement defects may be the culprit of disease in patients who present with
severe renal disease and often progress to ESRD, despite BP control. Methods We studied
a well defined cohort of 17 patients with hypertension-associated TMA to define the
prevalence of complement defects by a specific ex vivo serum-based microvascular …