[HTML][HTML] Treatment of paraquat-induced lung injury with an anti-C5a antibody: potential clinical application

S Sun, Y Jiang, R Wang, C Liu, X Liu, N Song… - Critical Care …, 2018 - journals.lww.com
Objectives: Complement activation product C5a plays a critical role in systemic inflammatory
response syndrome induced by viruses, bacteria, and toxic agents including paraquat
poisoning. This study is to explore the efficiency of anti-C5a–based intervention on systemic
inflammatory responses induced by paraquat poisoning. Design: Study of cynomolgus
macaque model and plasma from paraquat-poisoning patients. Setting: Laboratory
investigation. Subjects: Cynomolgus macaque (n= 12) and samples of plasma from patients …