Primary Sjögren's syndrome: new clinical and therapeutic concepts

M Ramos-Casals, AG Tzioufas, J Font - Annals of the rheumatic …, 2005 - ard.bmj.com
Annals of the rheumatic diseases, 2005ard.bmj.com
Sicca features are the central clinical manifestations of Sjögren's syndrome (SS), but recent
studies have confirmed that primary SS has a systemic expression, including extraglandular
manifestations. Patients with a predominantly extraepithelial expression should be managed
differently from patients with predominantly periepithelial or sicca limited disease. In coming
years treatment will be based on muscarinic agonists for sicca features and
immunosuppressive/biological agents for extraglandular features.
Sicca features are the central clinical manifestations of Sjögren’s syndrome (SS), but recent studies have confirmed that primary SS has a systemic expression, including extraglandular manifestations. Patients with a predominantly extraepithelial expression should be managed differently from patients with predominantly periepithelial or sicca limited disease. In coming years treatment will be based on muscarinic agonists for sicca features and immunosuppressive/biological agents for extraglandular features.
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