Similar to Parkinson disease, multiple system atrophy (MSA) presents neuropathologically
with nigral neuronal loss; however, the hallmark intracellular α-synuclein (αSyn)
accumulation in MSA affects typically oligodendrocytes to form glial cytoplasmic inclusions.
The underlying pathogenic mechanisms remain unclear. As MSA is predominantly sporadic,
epigenetic mechanisms may play a role. We tested the effects of the pan-histone
deacetylase inhibitor (HDACi) sodium phenylbutyrate in aged mice overexpressing αSyn …