Spinal cord repair strategies: why do they work?
EJ Bradbury, SB McMahon - Nature Reviews Neuroscience, 2006 - nature.com
Nature Reviews Neuroscience, 2006•nature.com
There are now numerous preclinical reports of various experimental treatments promoting
some functional recovery after spinal cord injury. Surprisingly, perhaps, the mechanisms that
underlie recovery have rarely been definitively established. Here, we critically evaluate the
evidence that regeneration of damaged pathways or compensatory collateral sprouting can
promote recovery. We also discuss several more speculative mechanisms that might
putatively explain or confound some of the reported outcomes of experimental interventions.
some functional recovery after spinal cord injury. Surprisingly, perhaps, the mechanisms that
underlie recovery have rarely been definitively established. Here, we critically evaluate the
evidence that regeneration of damaged pathways or compensatory collateral sprouting can
promote recovery. We also discuss several more speculative mechanisms that might
putatively explain or confound some of the reported outcomes of experimental interventions.
Abstract
There are now numerous preclinical reports of various experimental treatments promoting some functional recovery after spinal cord injury. Surprisingly, perhaps, the mechanisms that underlie recovery have rarely been definitively established. Here, we critically evaluate the evidence that regeneration of damaged pathways or compensatory collateral sprouting can promote recovery. We also discuss several more speculative mechanisms that might putatively explain or confound some of the reported outcomes of experimental interventions.
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