Successful creation of pancreatic cancer organoids by means of EUS-guided fine-needle biopsy sampling for personalized cancer treatment
H Tiriac, JC Bucobo, D Tzimas, S Grewel… - Gastrointestinal …, 2018 - Elsevier
Background and Aims Pancreatic cancer organoids are tumor models of individualized
human pancreatic ductal adenocarcinoma (PDA), created from surgical specimens and
used for personalized treatment strategies. Unfortunately, most patients with PDA are not
operative candidates. Creation of human PDA organoids at the time of initial tumor
diagnosis is therefore critical. Our aim was to assess the feasibility of creating human PDA
organoids by EUS fine-needle biopsy (EUS-FNB) sampling in patients with PDA. Methods In …
human pancreatic ductal adenocarcinoma (PDA), created from surgical specimens and
used for personalized treatment strategies. Unfortunately, most patients with PDA are not
operative candidates. Creation of human PDA organoids at the time of initial tumor
diagnosis is therefore critical. Our aim was to assess the feasibility of creating human PDA
organoids by EUS fine-needle biopsy (EUS-FNB) sampling in patients with PDA. Methods In …