Granulocyte–macrophage colony stimulating factor-mediated innate responses in tuberculosis
J Szeliga, DS Daniel, CH Yang, Z Sever-Chroneos… - Tuberculosis, 2008 - Elsevier
The mechanisms by which GM-CSF mediates bacterial clearance and inflammation during
mycobacterial infection are poorly understood. The objective of this work was to determine
how GM-CSF alters pulmonary mycobacterial infection in vivo. Differences in GM-CSF levels
in the lungs of normal mice (GM+/+), transgenic GM-CSF-deficient (GM-CSF−/−), and
transgenic mice with high GM-CSF expression only in lung epithelial cells (SP-C-GM-
CSF+/+/GM−/−) did not affect pulmonary infection rates caused by either the attenuated …
mycobacterial infection are poorly understood. The objective of this work was to determine
how GM-CSF alters pulmonary mycobacterial infection in vivo. Differences in GM-CSF levels
in the lungs of normal mice (GM+/+), transgenic GM-CSF-deficient (GM-CSF−/−), and
transgenic mice with high GM-CSF expression only in lung epithelial cells (SP-C-GM-
CSF+/+/GM−/−) did not affect pulmonary infection rates caused by either the attenuated …