[HTML][HTML] Breast milk immune complexes are potent inducers of oral tolerance in neonates and prevent asthma development
E Mosconi, A Rekima, B Seitz-Polski, A Kanda… - Mucosal …, 2010 - Elsevier
Allergic asthma is a chronic lung disease resulting from an inappropriate T helper (Th)-2
response to environmental antigens. Early tolerance induction is an attractive approach for
primary prevention of asthma. Here, we found that breastfeeding by antigen-sensitized
mothers exposed to antigen aerosols during lactation induced a robust and long-lasting
antigen-specific protection from asthma. Protection was more profound and persistent than
the one induced by antigen-exposed non-sensitized mothers. Milk from antigen-exposed …
response to environmental antigens. Early tolerance induction is an attractive approach for
primary prevention of asthma. Here, we found that breastfeeding by antigen-sensitized
mothers exposed to antigen aerosols during lactation induced a robust and long-lasting
antigen-specific protection from asthma. Protection was more profound and persistent than
the one induced by antigen-exposed non-sensitized mothers. Milk from antigen-exposed …