Nutrient regulation of pancreatic β-cell proliferation

VS Moullé, J Ghislain, V Poitout - Biochimie, 2017 - Elsevier
Excess consumption of energy-dense foods combined with a sedentary lifestyle is driving an
obesity epidemic. Although obesity is closely associated with insulin resistance, most
individuals meet the insulin demand by increasing their functional β-cell mass. Those who
eventually develop type 2 diabetes are distinguished by a failure in this compensatory
process. Although a causal role of insulin resistance in compensatory β-cell responses has
received considerable experimental support, precisely how the β cell senses changes in the …