[HTML][HTML] Deletion of fatty acid transport protein 2 (FATP2) in the mouse liver changes the metabolic landscape by increasing the expression of PPARα-regulated genes
Fatty acid transport protein 2 (FATP2) is highly expressed in the liver, small intestine, and
kidney, where it functions in both the transport of exogenous long-chain fatty acids and the
activation of very-long-chain fatty acids. Here, using a murine model, we investigated the
phenotypic impacts of deleting FATP2, followed by a transcriptomic analysis using unbiased
RNA-Seq to identify concomitant changes in the liver transcriptome. WT and FATP2-null
(Fatp2−/−) mice (5 weeks) were maintained on a standard chow diet for 6 weeks. The …
kidney, where it functions in both the transport of exogenous long-chain fatty acids and the
activation of very-long-chain fatty acids. Here, using a murine model, we investigated the
phenotypic impacts of deleting FATP2, followed by a transcriptomic analysis using unbiased
RNA-Seq to identify concomitant changes in the liver transcriptome. WT and FATP2-null
(Fatp2−/−) mice (5 weeks) were maintained on a standard chow diet for 6 weeks. The …