Safety of COX-2 inhibitors in asthma patients with aspirin hypersensitivity
PM West, C Fernández - Annals of Pharmacotherapy, 2003 - journals.sagepub.com
PM West, C Fernández
Annals of Pharmacotherapy, 2003•journals.sagepub.comObjective To review the safety of cyclooxygenase-2 (COX-2) inhibitors in asthma patients
with aspirin hypersensitivity. Data Sources Clinical studies were identified using MEDLINE
(1966–September 2002). Key search terms included cyclooxygenase inhibitors, aspirin,
asthma, and hypersensitivity. English-language articles were identified and included.
References from the identified articles were also reviewed. Data Synthesis The literature
provides information regarding the safety of COX-2 inhibitors in asthma patients with aspirin …
with aspirin hypersensitivity. Data Sources Clinical studies were identified using MEDLINE
(1966–September 2002). Key search terms included cyclooxygenase inhibitors, aspirin,
asthma, and hypersensitivity. English-language articles were identified and included.
References from the identified articles were also reviewed. Data Synthesis The literature
provides information regarding the safety of COX-2 inhibitors in asthma patients with aspirin …
Objective
To review the safety of cyclooxygenase-2 (COX-2) inhibitors in asthma patients with aspirin hypersensitivity.
Data Sources
Clinical studies were identified using MEDLINE (1966–September 2002). Key search terms included cyclooxygenase inhibitors, aspirin, asthma, and hypersensitivity. English-language articles were identified and included. References from the identified articles were also reviewed.
Data Synthesis
The literature provides information regarding the safety of COX-2 inhibitors in asthma patients with aspirin-exacerbated respiratory disease (AERD). The mechanism of AERD involves inhibition of cyclooxygenase, particularly COX-1. Inhibition of COX-1 causes an increased production of certain inflammatory mediators, which results in the reactions seen with AERD. Considering this mechanism, COX-2 inhibitors may be an alternative to aspirin or nonsteroidal antiinflammatory drugs (NSAIDs) in a patient with AERD. This article analyzes 4 studies to evaluate the safety of COX-2 inhibitors in this population.
Results
The 4 studies evaluated included a total of 172 patients with AERD. All patients included demonstrated intolerance to aspirin or NSAIDs and tolerated the selective COX-2 inhibitor administered.
Conclusions
COX-2 inhibitors provide a potentially safe alternative for treatment of inflammatory conditions in patients with AERD.
Sage Journals