[HTML][HTML] FGF-23 is a negative regulator of prenatal and postnatal erythropoiesis
LM Coe, SV Madathil, C Casu, B Lanske… - Journal of Biological …, 2014 - ASBMB
Abnormal blood cell production is associated with chronic kidney disease (CKD) and
cardiovascular disease (CVD). Bone-derived FGF-23 (fibroblast growth factor-23) regulates
phosphate homeostasis and bone mineralization. Genetic deletion of Fgf-23 in mice (Fgf-
23−/−) results in hypervitaminosis D, abnormal mineral metabolism, and reduced lymphatic
organ size. Elevated FGF-23 levels are linked to CKD and greater risk of CVD, left
ventricular hypertrophy, and mortality in dialysis patients. However, whether FGF-23 is …
cardiovascular disease (CVD). Bone-derived FGF-23 (fibroblast growth factor-23) regulates
phosphate homeostasis and bone mineralization. Genetic deletion of Fgf-23 in mice (Fgf-
23−/−) results in hypervitaminosis D, abnormal mineral metabolism, and reduced lymphatic
organ size. Elevated FGF-23 levels are linked to CKD and greater risk of CVD, left
ventricular hypertrophy, and mortality in dialysis patients. However, whether FGF-23 is …